Setyaningsih, Reni (2025) FORMULASI CLAY MASK EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) DENGAN VARIASI KONSENTRASI KAOLIN DAN UJI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH. Other thesis, Universitas Setia Budi.
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Abstract
Daun kersen (Muntingia calabura L.) mengandung senyawa
senyawa aktif yaitu flavonoid, saponin, tanin dan vitamin C.
Senyawa flavonoid dan vitamin C mempunyai aktivitas untuk
antioksidan. Penelitian Fitriyanti et al., (2017) menemukan bahwa
memiliki IC50 sebesar 42,354 ppm sedangkan komponen quercetin
dari daun kersen memiliki nilai IC50 sebesar 6,8249 ppm. Penelitian
ini bertujuan agar mengetahui mutu fisik serta stabilitas Clay mask
ekstrak etanol daun kersen (Muntingia calabura L.) yang divariasi
kaolin terhadap aktivitas antioksidan.
Ekstraksi daun kersen dengan metode maserasi menggunakan
etanol 96%. Konsentrasi ekstrak yang digunakan pada formulasi
sediaan Clay mask 3% dengan variasi kaolin 30%, 35% dan 40% di
uji mutu Fisik eliputi uji organoleptis, uji homogenitas, uji pH, uji
viskositas, uji waktu kering, uji daya sebar, uji daya lekat, uji
kesukaan (hedonic), uji iritasi, dan uji stabilitas. Penentuan aktivitas
antioksidan dilakukan menggunakan metode peredaman radikal bebas
DPPH dengan menghitung nilai IC50. Data hasil penelitian dianalisis
statistik menggunakan One Way Anova.
Hasil penelitian menunjukan Sediaan Clay mask daun kersen
(Muntingia calabura L.) dengan variasi konsentrasi kaolin 35% (F2)
menghasilkan mutu fisik serta stabilitas yang baik. Sediaan tidak
mengiritasi dan memenuhi tingkat kesukaan diterima serta memiliki
aktivitas antioksidan dalam kategori sedang dengan nilai IC50 146
μg/mL.
Kersen leaves (Muntingia calabura L.) contain active compounds,
namely flavonoids, saponins, tannins and vitamin C. Flavonoids and
vitamin C have antioxidant activity. Research by Fitriyanti et al., (2017)
found that it had an IC50 of 42.354 ppm, while the quercetin component
from cherry leaves had an IC50 value of 6.8249 ppm. This research aims to
determine the physical quality and stability of Clay mask with ethanol
extract of cherry leaves (Muntingia calabura L.) varied with kaolin on
antioxidant activity.
Extraction of cherry leaves using the maceration method using 96%
ethanol. The extract concentration used in the Clay mask preparation
formulation was 3% with kaolin variations of 30%, 35% and 40% in
physical quality tests including organoleptic tests, homogeneity tests, pH
tests, viscosity tests, dry time tests, spreadability tests, adhesion tests,
hedonic tests, irritation tests and stability tests. Determination of antioxidant
activity was carried out using the DPPH free radical scavenging method by
calculating the IC50 value. The research data was analyzed statistically using
One Way Anova.
The results of the study showed that the Clay mask preparation of
cherry leaves (Muntingia calabura L.) with a kaolin concentration variation
of 35% (F2) produced good physical quality and stability. The preparation
was non-irritating and met the acceptable level of preference and had
antioxidant activity in the moderate category with an IC50 value of 146
μg/mL.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Kersen leaf ethanol extract, Clay mask, Kaolin Variation, Antioxidant Ekstrak etanol daun kersen, Clay mask, Variasi Kaolin, Antioksidan |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Universitas Setia Budi > Fakultas Farmasi > S1 Farmasi |
| Depositing User: | Unnamed user with email baa.si@setiabudi.ac.id |
| Date Deposited: | 23 Dec 2025 07:25 |
| Last Modified: | 23 Dec 2025 07:25 |
| URI: | https://eprints.setiabudi.ac.id/id/eprint/104 |
