FORMULASI CLAY MASK EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) DENGAN VARIASI KONSENTRASI KAOLIN DAN UJI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH

Setyaningsih, Reni (2025) FORMULASI CLAY MASK EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) DENGAN VARIASI KONSENTRASI KAOLIN DAN UJI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH. Other thesis, Universitas Setia Budi.

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Abstract

Daun kersen (Muntingia calabura L.) mengandung senyawa senyawa aktif yaitu flavonoid, saponin, tanin dan vitamin C. Senyawa flavonoid dan vitamin C mempunyai aktivitas untuk antioksidan. Penelitian Fitriyanti et al., (2017) menemukan bahwa memiliki IC50 sebesar 42,354 ppm sedangkan komponen quercetin dari daun kersen memiliki nilai IC50 sebesar 6,8249 ppm. Penelitian ini bertujuan agar mengetahui mutu fisik serta stabilitas Clay mask ekstrak etanol daun kersen (Muntingia calabura L.) yang divariasi kaolin terhadap aktivitas antioksidan. Ekstraksi daun kersen dengan metode maserasi menggunakan etanol 96%. Konsentrasi ekstrak yang digunakan pada formulasi sediaan Clay mask 3% dengan variasi kaolin 30%, 35% dan 40% di uji mutu Fisik eliputi uji organoleptis, uji homogenitas, uji pH, uji viskositas, uji waktu kering, uji daya sebar, uji daya lekat, uji kesukaan (hedonic), uji iritasi, dan uji stabilitas. Penentuan aktivitas antioksidan dilakukan menggunakan metode peredaman radikal bebas DPPH dengan menghitung nilai IC50. Data hasil penelitian dianalisis statistik menggunakan One Way Anova. Hasil penelitian menunjukan Sediaan Clay mask daun kersen (Muntingia calabura L.) dengan variasi konsentrasi kaolin 35% (F2) menghasilkan mutu fisik serta stabilitas yang baik. Sediaan tidak mengiritasi dan memenuhi tingkat kesukaan diterima serta memiliki aktivitas antioksidan dalam kategori sedang dengan nilai IC50 146 μg/mL. Kersen leaves (Muntingia calabura L.) contain active compounds, namely flavonoids, saponins, tannins and vitamin C. Flavonoids and vitamin C have antioxidant activity. Research by Fitriyanti et al., (2017) found that it had an IC50 of 42.354 ppm, while the quercetin component from cherry leaves had an IC50 value of 6.8249 ppm. This research aims to determine the physical quality and stability of Clay mask with ethanol extract of cherry leaves (Muntingia calabura L.) varied with kaolin on antioxidant activity. Extraction of cherry leaves using the maceration method using 96% ethanol. The extract concentration used in the Clay mask preparation formulation was 3% with kaolin variations of 30%, 35% and 40% in physical quality tests including organoleptic tests, homogeneity tests, pH tests, viscosity tests, dry time tests, spreadability tests, adhesion tests, hedonic tests, irritation tests and stability tests. Determination of antioxidant activity was carried out using the DPPH free radical scavenging method by calculating the IC50 value. The research data was analyzed statistically using One Way Anova. The results of the study showed that the Clay mask preparation of cherry leaves (Muntingia calabura L.) with a kaolin concentration variation of 35% (F2) produced good physical quality and stability. The preparation was non-irritating and met the acceptable level of preference and had antioxidant activity in the moderate category with an IC50 value of 146 μg/mL.
Item Type: Thesis (Other)
Uncontrolled Keywords: Kersen leaf ethanol extract, Clay mask, Kaolin Variation, Antioxidant Ekstrak etanol daun kersen, Clay mask, Variasi Kaolin, Antioksidan
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Universitas Setia Budi > Fakultas Farmasi > S1 Farmasi
Depositing User: Unnamed user with email baa.si@setiabudi.ac.id
Date Deposited: 23 Dec 2025 07:25
Last Modified: 23 Dec 2025 07:25
URI: https://eprints.setiabudi.ac.id/id/eprint/104

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