Damayanti, Marcella Ameilia (2025) POTENSI EKSTRAK ETANOL UMBI RUMPUT TEKI (Cyperus rotundus) SEBAGAI SEDIAAN KRIM ANTIBAKTERI Staphylococcus aureus. Other thesis, Universitas Setia Budi.
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Abstract
Prevalensi penyakit kulit di Indonesia cukup tinggi dengan
persentase 28%. Rimpang rumput teki dapat menjadi alternatif sebagai
antibakteri. Krim dapat menjadi sediaan yang menguntungkan karena
mudah dibilas air dan permeabilitas yang baik. Penelitian ini bertujuan
mengetahui aktivitas antibakteri dari krim ekstrak rimpang rumput teki
terhadap Staphylococcus aureus dengan variasi asam stearat dan
paraffin cair.
Ekstrak etanol rimpang rumput teki diperoleh dengan metode
ultrasonik dengan etanol 96%. Ekstrak dilakukan optimasi antibakteri
pada media MHA dengan konsentrasi 5%; 7,5%; dan 10%. Ekstrak
dibuat sediaan krim dengan menvariasikan asam stearat dan paraffin
cair sebagai emulgator. Sediaan krim diuji mutu fisik meliputi uji
organoleptis, homogenitas, pH, viskositas, daya sebar, daya lekat, uji
dan pengujian aktivitas antibakteri dengan metode cakram. Hasil
dianalisis menggunakan SPSS jika terdistribusi normal (P-Value >
0,05) maka dilanjutkan dengan menggunakan uji ANOVA< jika
terdistribusi tidak normal P-Value < 0,05) maka dilanjutkan dengan uji
Kruskal Wallis.
Hasil penelitian menunjukkan variasi asam stearat dan parafin
cair berpengaruh terhadap viskositas, daya sebar, dan daya lekat dapat
memberikan perbedaan pada mutu fisik. PH krim memiliki kisaran 6,17
sampai 6,35. Viskositas pada rentang 3920,0 – 8286,7 Cp. Daya lekat
semua formula lebih dari 1 detik. Daya sebar tertinggi pada F6 dengan
diameter 4,5 cm. F6 dengan variasi asam stearat 20 dan 5 gram parafin
cair merupakan formulasi krim yang paling optimal dengan mutu fisik
dan stabilitas yang baik yang memiliki diameter daya hambat 16,86 cm.
The prevalence of skin diseases in Indonesia is relatively high,
with a percentage of 28%. Purple nutsedge (Cyperus rotundus) rhizome
can serve as an alternative antibacterial agent. Cream formulations offer
advantages due to their ease of rinsing with water and good
permeability. This study aims to determine the antibacterial activity of
purple nutsedge rhizome extract cream against Staphylococcus aureus,
with variations in stearic acid and liquid paraffin.
The ethanol extract of purple nutsedge rhizome was obtained
using the ultrasonic method with 96% ethanol. The antibacterial
activity of the extract was optimized on Mueller-Hinton Agar (MHA)
at concentrations of 5%; 7.5%; and 10%. The extract was formulated
into a cream by varying the stearic acid and liquid paraffin content. The
cream formulations were evaluated for physical quality, including
organoleptic tests, homogeneity, pH, viscosity, spreadability, adhesion,
and antibacterial activity using the disk diffusion method. The results
were statistically analyzed using SPSS; if normally distributed (P�Value > 0.05), an ANOVA test was conducted, whereas if not normally
distributed (P-Value < 0.05), the Kruskal-Wallis test was used.
The results showed that variations in stearic acid and liquid
paraffin affected viscosity, spreadability, and adhesion, leading to
differences in physical quality. The pH of the cream ranged from 6.17
to 6.35. The viscosity was between 3,920 and 8,286.7 cP. The adhesion
time for all formulations exceeded 1 second. The highest spreadability
was observed in formulation F6, with a diameter of 4.5 cm.
Formulation F6 was the most optimal cream formulation, exhibiting
good physical quality and an inhibition zone diameter of 16.86 cm.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Cyperus rotundus, cream, antibacterial, Staphylococcus aureus rimpang rumput teki, krim, antibakteri, Staphylococcus aureus |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Universitas Setia Budi > Fakultas Farmasi > S1 Farmasi |
| Depositing User: | Unnamed user with email baa.si@setiabudi.ac.id |
| Date Deposited: | 05 Jan 2026 02:11 |
| Last Modified: | 05 Jan 2026 02:11 |
| URI: | https://eprints.setiabudi.ac.id/id/eprint/227 |
