Sari, Indriana (2022) FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN KRIM KUNYIT PUTIH (Curcuma zedoaria (Berg.) Roscoe) DENGAN KOMBINASI TWEEN 80 DAN SPAN 80 SEBAGAI EMULGATOR. Other thesis, Universitas Setia Budi.
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Abstract
Kunyit putih mengandung flavonoid yang dipercaya mampu
mengurangi dampak dari radikal bebas tertentu. Ekstrak kunyit putih
diformulasikan menjadi sediaan krim agar dalam penggunaanyabisa
lebih nyaman, efektif dan efisien. Penelitian ini bertujuan untuk
mengetahui potensi antioksidan ekstrak kunyit putih, pengaruh variasi
kombinasi emulgator tween 80 dan span 80 terhadap mutu fisik dan
stabilitas sediaan krim ekstrak kunyit.
Krim diformulasi dengan variasi kombinasi emulgator F1 Tween
80;Span 80 (4,4%;5,6%), F2 Tween 80; Span 80 (5,8% ;4,2%), F3
Tween 80;Span 80 (7,2%; 2,8%). Pengujian mutu fisik sediaan
mencakup uji organoleptis, homogenitas, pH, viskositas, daya sebar,
daya lekat, tipe krim dan cycling test. Data absorbansi digunakan untuk
mengukur IC50. Hasil data dianalisis menggunakan One-way ANOVA
dengan taraf kepercayaan 95%.
Hasil penelitian menunjukkan bahwa peningkatan konsentrasi
emulgator berpengaruh terhadap meningkatnya viskositas,
meningkaynya daya lekat dan menurunnya daya sebar dan pH menurun.
Hasil uji aktivitas antioksidan menunjukkan IC50 formula 1, formula 2
dan formula 3 berturut-turut adalah 68,01 ppm, 64,47 ppm, 61,32 ppm.
Formula 3 merupakan formula sediaan krim antioksidan ekstrak kunyit
putih yang mempunyai aktivitas paling baik terhadap antioksidan secara
DPPH.
White turmeric contains flavonoids believed to reduce certain
free radicals' impact. Therefore, white turmeric extract is formulated into
cream preparations to make its use more comfortable, effective, and
efficient. This study aims to determine the antioxidant potential of white
turmeric extract and the effect of variations in the combination of
emulsifier tween 80 and span 80 on the physical quality and stability of
turmeric extract cream preparations.
The cream is formulated with various combinations of emulsifier
F1 Tween 80; Span 80 (4.4%;5.6%), F2 Tween 80; Span 80
(5.8% ;4.2%), F3 Tween 80; Span 80 (7.2%; 2.8%). The physical quality
test of the preparation includes organoleptic test, homogeneity, pH,
viscosity, spreadability, adhesion, cream type, and cycling test.
Absorbance data is used to measure IC50. The data results were analyzed
using One-way ANOVA with a 95% confidence level.
The results showed that increasing the emulsifier concentration
affected increasing viscosity, increasing adhesion, also decreasing
dispersion and pH. The results of the antioxidant activity test showed that
the IC50 of formula 1, formula 2 and formula 3 were 68,01 ppm, 64,47
ppm, and 61,32 ppm, respectively. Formula 3 is an antioxidant cream
formulation from white turmeric extract with the best activity against
antioxidants by DPPH.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | antioxidant, white turmeric extract, cream preparation, span 80, tween 80. antioksidan, esktrak kunyit putih, sediaan krim, span 80, tween 80. |
| Subjects: | Q Science > QK Botany R Medicine > R Medicine (General) R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Universitas Setia Budi > Fakultas Farmasi > S1 Farmasi |
| Depositing User: | Unnamed user with email baa.si@setiabudi.ac.id |
| Date Deposited: | 08 Jan 2026 07:37 |
| Last Modified: | 08 Jan 2026 07:37 |
| URI: | https://eprints.setiabudi.ac.id/id/eprint/288 |
