Amanda, Dela (2025) EVALUASI PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN STROKE ISKEMIK DI INSTALASI RAWAT INAP RUMAH SAKIT UNS. Other thesis, Universitas Setia Budi.
ABSTRAK.pdf
Download (92kB)
Form Pernyataan Publikasi.pdf
Download (172kB)
SK CEK PLAGIASI_CANTIKA HUSNA NOVERA.pdf
Download (162kB)
BAB I.pdf
Download (754kB)
BAB II.pdf
Download (2MB)
BAB III.pdf
Download (263kB)
BAB IV.pdf
Restricted to Repository staff only
Download (9MB)
BAB V.pdf
Restricted to Repository staff only
Download (87kB)
DAFTAR PUSTAKA.pdf
Restricted to Repository staff only
Download (264kB)
LAMPIRAN.pdf
Restricted to Repository staff only
Download (593kB)
Abstract
Stroke merupakan penyebab kematian terbesar di Indonesia dan
penyakit stroke ini termasuk kedalam 10 besar penyakit di rumah sakit
UNS, pengobatan stroke melibatkan banyan obat dan memerlukan
jangka waktu yang panjang, maka penelitian ini perlu dilakukan karena
pada Rumah Sakit UNS memiliki jumlah kasus stroke iskemik dan
hipertensi yang cukup tinggi, sehingga menjadi lokasi yang
representatif untuk meneliti penggunaan obat antihipertensi secara
rasional. Tujuan penelitian ini adalah untuk mengevaluasi rasionalitas
penggunaan obat antihipertensi pada pasien stroke iskemik.
Penelitian ini menggunakan desain observasional dengan
pendekatan retrospektif dan bersifat deskriptif analitik. Data diperoleh
melalui rekam medis pasien stroke iskemik yang dirawat di Instalasi
Rawat Inap RS UNS periode Januari–Desember 2024. Sampel dipilih
dengan teknik purposive sampling berdasarkan kriteria inklusi seperti
pasien terdiagnosis stroke iskemik, menerima terapi antihipertensi, dan
memiliki data tekanan darah lengkap, analisis dilakukan secara
univariat untuk mempersentasekan hasil dan bivariat untuk mengetahui
adanya hubungan antara rasionalitas penggunaan obat dengan outcome
klinis berupa penurunan tekanan darah.
Hasil penelitian menunjukkan bahwa obat yang paling banyak
digunakan adalah amlodipine, dan mayoritas terapi telah sesuai dengan
pedoman JNC VIII. Tingkat rasionalitas mencapai 100% pada aspek
indikasi, pasien, dan dosis, serta 89,3% pada pemilihan obat. Uji
korelasi menunjukkan hubungan yang sangat kuat antara rasionalitas
terapi ketepatan obat dan outcome tekanan darah (p = 0,000) p< 0,05.
Stroke is the leading cause of death in Indonesia and is among
the top 10 diseases treated at UNS Hospital. Stroke treatment involves
multiple medications and requires a prolonged treatment period.
Therefore, this study is considered necessary, as UNS Hospital has a
high number of ischemic stroke and hypertension cases, making it a
representative site for evaluating the rational use of antihypertensive
drugs. The aim of this study is to evaluate the rationality of
antihypertensive drug use in ischemic stroke patients.
This study employed an observational design with a
retrospective and descriptive-analytic approach. Data were obtained
from the medical records of ischemic stroke patients who were
hospitalized in the Inpatient Unit of UNS Hospital during the period of
January to December 2024. Samples were selected using purposive
sampling based on inclusion criteria, such as patients diagnosed with
ischemic stroke, receiving antihypertensive therapy, and having
complete blood pressure data. The analysis was conducted univariately
to present percentages and bivariately to determine the relationship
between the rationality of drug use and clinical outcomes in the form of
blood pressure reduction.
The results showed that the most commonly used drug was
amlodipine, and the majority of therapies adhered to the JNC VIII
guidelines. The level of rationality reached 100% in terms of
indication, patient, and dosage, and 89.3% in drug selection.
Correlation testing indicated a very strong relationship between the
rationality of drug accuracy and blood pressure outcomes (p = 0.000; p
< 0.05)
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | ischemic stroke, antihypertensive drugs, drug rationality, JNC VIII stroke iskemik, obat antihipertensi, rasionalitas obat, JNC VIII |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Universitas Setia Budi > Fakultas Farmasi > S1 Farmasi |
| Depositing User: | Unnamed user with email baa.si@setiabudi.ac.id |
| Date Deposited: | 22 Dec 2025 04:44 |
| Last Modified: | 22 Dec 2025 04:44 |
| URI: | https://eprints.setiabudi.ac.id/id/eprint/31 |
