EVALUASI PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN STROKE ISKEMIK DI INSTALASI RAWAT INAP RUMAH SAKIT UNS

Amanda, Dela (2025) EVALUASI PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN STROKE ISKEMIK DI INSTALASI RAWAT INAP RUMAH SAKIT UNS. Other thesis, Universitas Setia Budi.

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Abstract

Stroke merupakan penyebab kematian terbesar di Indonesia dan penyakit stroke ini termasuk kedalam 10 besar penyakit di rumah sakit UNS, pengobatan stroke melibatkan banyan obat dan memerlukan jangka waktu yang panjang, maka penelitian ini perlu dilakukan karena pada Rumah Sakit UNS memiliki jumlah kasus stroke iskemik dan hipertensi yang cukup tinggi, sehingga menjadi lokasi yang representatif untuk meneliti penggunaan obat antihipertensi secara rasional. Tujuan penelitian ini adalah untuk mengevaluasi rasionalitas penggunaan obat antihipertensi pada pasien stroke iskemik. Penelitian ini menggunakan desain observasional dengan pendekatan retrospektif dan bersifat deskriptif analitik. Data diperoleh melalui rekam medis pasien stroke iskemik yang dirawat di Instalasi Rawat Inap RS UNS periode Januari–Desember 2024. Sampel dipilih dengan teknik purposive sampling berdasarkan kriteria inklusi seperti pasien terdiagnosis stroke iskemik, menerima terapi antihipertensi, dan memiliki data tekanan darah lengkap, analisis dilakukan secara univariat untuk mempersentasekan hasil dan bivariat untuk mengetahui adanya hubungan antara rasionalitas penggunaan obat dengan outcome klinis berupa penurunan tekanan darah. Hasil penelitian menunjukkan bahwa obat yang paling banyak digunakan adalah amlodipine, dan mayoritas terapi telah sesuai dengan pedoman JNC VIII. Tingkat rasionalitas mencapai 100% pada aspek indikasi, pasien, dan dosis, serta 89,3% pada pemilihan obat. Uji korelasi menunjukkan hubungan yang sangat kuat antara rasionalitas terapi ketepatan obat dan outcome tekanan darah (p = 0,000) p< 0,05. Stroke is the leading cause of death in Indonesia and is among the top 10 diseases treated at UNS Hospital. Stroke treatment involves multiple medications and requires a prolonged treatment period. Therefore, this study is considered necessary, as UNS Hospital has a high number of ischemic stroke and hypertension cases, making it a representative site for evaluating the rational use of antihypertensive drugs. The aim of this study is to evaluate the rationality of antihypertensive drug use in ischemic stroke patients. This study employed an observational design with a retrospective and descriptive-analytic approach. Data were obtained from the medical records of ischemic stroke patients who were hospitalized in the Inpatient Unit of UNS Hospital during the period of January to December 2024. Samples were selected using purposive sampling based on inclusion criteria, such as patients diagnosed with ischemic stroke, receiving antihypertensive therapy, and having complete blood pressure data. The analysis was conducted univariately to present percentages and bivariately to determine the relationship between the rationality of drug use and clinical outcomes in the form of blood pressure reduction. The results showed that the most commonly used drug was amlodipine, and the majority of therapies adhered to the JNC VIII guidelines. The level of rationality reached 100% in terms of indication, patient, and dosage, and 89.3% in drug selection. Correlation testing indicated a very strong relationship between the rationality of drug accuracy and blood pressure outcomes (p = 0.000; p < 0.05)
Item Type: Thesis (Other)
Uncontrolled Keywords: ischemic stroke, antihypertensive drugs, drug rationality, JNC VIII stroke iskemik, obat antihipertensi, rasionalitas obat, JNC VIII
Subjects: R Medicine > R Medicine (General)
Divisions: Universitas Setia Budi > Fakultas Farmasi > S1 Farmasi
Depositing User: Unnamed user with email baa.si@setiabudi.ac.id
Date Deposited: 22 Dec 2025 04:44
Last Modified: 22 Dec 2025 04:44
URI: https://eprints.setiabudi.ac.id/id/eprint/31

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