PENGARUH KONSENTRASI CARBOPOL 940 SEBAGAI GELLING AGENT TERHADAP STABILITAS MUTU FISIK DAN AKTIVITAS ANTIOKSIDAN SEDIAAN GEL EKSTRAK BUAH MENTIMUN (Cucumis sativus.L.)

Restiani, Devina Anggrea (2025) PENGARUH KONSENTRASI CARBOPOL 940 SEBAGAI GELLING AGENT TERHADAP STABILITAS MUTU FISIK DAN AKTIVITAS ANTIOKSIDAN SEDIAAN GEL EKSTRAK BUAH MENTIMUN (Cucumis sativus.L.). Other thesis, Universitas Setia Budi.

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Abstract

Mentimun memiliki khasiat yang sangat banyak, mentimun juga memiliki kandungan yang dapat sebagai penyangkal radikal bebas atau sering disebut sebagai antioksidan. Mentimun dibuat menjadi gel untuk meningkatkan nilai praktis yang berfungsi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi carbopol 940 sebagai gelling agent terhadap stabilitas mutu fisik. Mentimun diekstraksi menggunakan etanol 70% dengan metode maserasi. Sediaan gel ekstrak mentimun dibuat menjadi 3 variasi konsentrasi carbopol 940 1%; 1,5%; dan 2%, yang kemudian diuji mutu fisik. Kandungan antioksidan dalam gel diukur menggunakan metode DPPH. Data selanjutnya akan diolah menggunakan metode One-way ANOVA dan post hoc Tukey HSD. Hasil stabilitas fisik diolah menggunakan metode paired T-test. Hasil pengujian sifat fisik / stabilitas fisik menunjukkan bahwa sediaan FI, FII, dan FIII memenuhi syarat pengujian organoleptis, homogenitas, viskositas, pH, daya sebar,daya lekat, serta stabilitas.Sediaan gel memiliki aktivitas antioksidan dengan rata – rata IC50 75,60 ppm yang tergolong kuat dengan range IC50 50 -100 ppm adalah kuat. Cucumber (Cucumis sativus L.) has numerous health benefits, including its ability to act as a free radical scavenger, often referred to as an antioxidant. In this study, cucumber is formulated into a gel to enhance its practical value as an antioxidant. The aim of this research is to determine the effect of Carbopol 940 concentration as a gelling agent on the physical stability quality. Cucumbers were extracted using 70% ethanol through a maceration method. The gel formulations of cucumber extract were created with three variations of Carbopol 940 concentrations: 1%, 1.5%, and 2%, which were then tested for physical quality. The antioxidant content in the gel was measured using the DPPH method. The data will be analyzed using One-way ANOVA and post hoc Tukey HSD tests, while the results of the physical stability tests will be processed using paired T-tests. The results of the physical stability tests indicate that formulations FI, FII, and FIII meet the criteria for organoleptic testing, homogeneity, viscosity, pH, spreadability, adhesiveness, and stability. The gel formulations exhibited antioxidant activity with an average IC50 of 75.60 ppm, categorizing it as strong since the range for strong activity is between 50 - 100 ppm.
Item Type: Thesis (Other)
Uncontrolled Keywords: Antioksidan, Gel, Mentimun, Carbopol 940, Stabilitas Fisik, DPPH Antioxidant, Gel, Cucumber, Carbopol 940, Physical Stability, DPPH
Subjects: Q Science > Q Science (General)
Q Science > QK Botany
Divisions: Universitas Setia Budi > Fakultas Farmasi > S1 Farmasi
Depositing User: Unnamed user with email baa.si@setiabudi.ac.id
Date Deposited: 22 Dec 2025 06:52
Last Modified: 22 Dec 2025 06:52
URI: https://eprints.setiabudi.ac.id/id/eprint/36

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