UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAN FRAKSI DAUN ALPUKAT (Persea americana Mill.) PADA TIKUS PUTIH (Rattus norvegicus) JANTAN YANG DIINDUKSI KARAGENIN 1%

Inflammation is a tissue response to irritation, infection or foreign body which aims to protect the individual. Avocado leaves (Persea americana Mill.) contain chemical compounds in the form of flavonoids, saponins, tannins, and alkaloids that have the potential as anti-inflammatory. This study aims to prove the anti-inflammatory effect of avocado leaves extract and fraction (Persea americana Mill. on the soles of white rats (Rattus novergicus) induced by carrageenin. Avocado leaf extract was prepared by maceration method with 96% ethanol solvent. The extract was then fractionated by liquid extraction method. Liquid using n-hexane, ethyl acetate, and water as a solvent. The results of the avocado leaves fraction were tested for anti inflammatory activity against edema in white rats (Rattus novergicus) that had been induced by carrageenin. Then the fraction which had the best activity as anti-inflammatory was observed. Mouse paws were statistically analyzed using SPSS. The anti-inflammatory activity test showed that the extract and fraction of n-hexane, ethyl acetate, and water in avocado leaves had anti-inflammatory activity with DAI percentage values of 80.0402%, 80.0457%, 88.2156%, 67.8651%. The ethyl acetate fraction as the most active fraction and a group of compounds that have potential as anti inflammatories are flavonoids, saponin, tannin, and steroid.