Nahak, Maria Magdalena Nahak 27216624A (2025) PENGARUH PEMBERIAN ERITROPOIETIN TERHADAP OUTCOME TERAPI PADA PASIEN GAGAL GINJAL KRONIK DENGAN HEMODIALISA DI RSUD BUNG KARNO KOTA SURAKARTA. Other thesis, Universitas Setia Budi.
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Abstract
Penyakit Ginjal Kronis (PGK) sering menyebabkan anemia pada
pasien hemodialisis akibat defisiensi eritropoietin. Terapi eritropoietin
(EPO) penting untuk meningkatkan hemoglobin (Hb) dan hematokrit
(HCT), serta memperbaiki kualitas hidup. Penelitian ini mengkaji
karakteristik pasien dan efektivitas pengobatan eritropoietin di RSUD
Bung Karno Surakarta.
Penelitian observasional deskriptif retrospektif ini menganalisis
rekam medis 81 pasien PGK stadium 4-5 yang menjalani hemodialisis
dan menerima EPO di RSUD Bung Karno (Januari-Desember 2024).
Data karakteristik, Hb, dan HCT sebelum-sesudah terapi dianalisis
menggunakan statistik deskriptif dan paired sample t-test.
Hasil penelitian menunjukan Mayoritas pasien EPO tunggal
adalah perempuan (45-59 tahun, stadium 4), sementara kelompok
kombinasi EPO+asam folat didominasi laki-laki (38-59 tahun, stadium
4). Kedua terapi signifikan meningkatkan Hb dan HCT setelah 4 minggu
(p 0,001). Kombinasi EPO+asam folat menunjukkan hasil klinis yang
lebih baik dalam penanganan anemia. Eritropoietin, baik tunggal
maupun kombinasi dengan asam folat, efektif meningkatkan hemoglobin
dan hematokrit pada pasien PGK hemodialisis. Kombinasi EPO dan
asam folat memberikan hasil yang lebih optimal untuk penanganan
anemia.
Chronic Kidney Disease (CKD) often causes anemia in
hemodialysis patients due to erythropoietin deficiency. Erythropoietin
(EPO) therapy is important to increase hemoglobin (Hb) and hematocrit
(HCT), and improve quality of life. This study examined patient
characteristics and effectiveness of erythropoietin treatment at Bung
Karno Hospital in Surakarta.
This retrospective descriptive observational study analyzed the
medical records of 81 stage 4-5 CKD patients who underwent
hemodialysis and received EPO at Bung Karno Hospital (January�December 2024). Data on characteristics, Hb, and HCT before-after
therapy were analyzed using descriptive statistics and paired sample t�test.
The results showed that the majority of single EPO patients were
female (45-59 years, stage 4), while the EPO + folic acid combination
group was dominated by men (38-59 years, stage 4). Both therapies
significantly improved Hb and HCT after 4 weeks (p 0.001). The
combination of EPO + folic acid showed better clinical results in the
treatment of anemia. Erythropoietin, either alone or in combination with
folic acid, is effective in increasing hemoglobin and hematocrit in
hemodialysis CKD patients.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Penyakit Ginjal Kronis, Hemodialisis, Anemia, Eritropoietin, Asam Folat, Hemoglobin, Hematokrit. Chronic Kidney Disease, Hemodialysis, Anemia, Erythropoietin, Folic Acid, Hemoglobin, Hematocrit. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Universitas Setia Budi > Fakultas Farmasi > S1 Farmasi |
| Depositing User: | Unnamed user with email baa.si@setiabudi.ac.id |
| Date Deposited: | 23 Dec 2025 03:05 |
| Last Modified: | 23 Dec 2025 03:05 |
| URI: | https://eprints.setiabudi.ac.id/id/eprint/79 |
