Krista, El Shadday Bela (2025) EFEKTIVITAS KORTIKOSTEROID DALAM MENINGKATKAN TROMBOSIT PADAPASIEN DEMAM BERDARAH DENGUE DI RSUD Dr. MOEWARDI SURAKARTA : PERIODE JANUARI 2023 - DESEMBER 2024. Other thesis, Universitas Setia Budi.
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Abstract
Demam Berdarah Dengue (DBD) merupakan penyakit infeksi
yang ditandai dengan penurunan jumlah trombosit (trombositopenia),
yang dapat mempengaruhi tingkat kesembuhan pasien. Kortikosteroid
seperti deksametason diketahui memiliki efek antiinflamasi dan
imunosupresif yang berpotensi meningkatkan jumlah trombosit.
Penelitian ini bertujuan untuk mengevaluasi efektivitas kortikosteroid
dalam meningkatkan trombosit pada pasien DBD, serta
membandingkan kecepatan pemulihan jumlah trombosit antara pasien
yang mendapatkan terapi kortikosteroid dan non steroid.
Penelitian ini menggunakan desain observasional retrospektif
dengan data rekam medis pasien DBD di RSUD Dr. Moewardi
Surakarta pada periode Januari 2023 hingga Desember 2024. Sampel
dipilih secara purposive sampling sebanyak 56 pasien yang memenuhi
kriteria inklusi dan eksklusi. Data jumlah trombosit sebelum dan
sesudah pemberian terapi dianalisis menggunakan uji statistik Mann�Whitney.
Hasil penelitian menunjukkan bahwa terdapat perbedaan yang
signifikan antara kelompok pasien yang diberi terapi kortikosteroid dan
yang tidak. Namun, peningkatan trombosit rata-rata lebih tinggi pada
kelompok tanpa kortikosteroid. Hal ini menunjukkan bahwa
penggunaan kortikosteroid belum tentu memberikan hasil klinis yang
lebih baik dalam pengelolaan pasien DBD.
Dengue Hemorrhagic Fever (DHF) is an infectious disease
characterized by a decrease in the number of platelets
(thrombocytopenia), which can affect the patient's recovery rate.
Corticosteroids such as dexamethasone are known to have anti�inflammatory and immunosuppressive effects that have the potential to
increase platelet count. This study aimed to evaluate the effectiveness
of corticosteroids in increasing platelets in Dengue patients, as well as
to compare the recovery rate of platelet counts between patients
receiving corticosteroid and non- steroidal therapy.
This study used a retrospective observational design with medical
record data of Dengue patients at Dr. Moewardi Surakarta Hospital in
the period January 2023 to December 2024. The sample was selected by
purposive sampling of 56 patients who met the inclusion and exclusion
criteria. Data on platelet counts before and after therapy were analyzed
using Mann-Whitney statistical tests.
The results showed that there were significant differences between
the groups of patients who were given corticosteroid therapy and those
who were not. However, the average platelet increase was higher in the
group without corticosteroids. This suggests that the use of
corticosteroids does not necessarily provide better clinical outcomes in
the management of Dengue patients.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Demam Berdarah Dengue, trombositopenia, kortikosteroid, analisis retrospektif. Dengue Hemorrhagic Fever, thrombocytopenia, corticosteroids, retrospective analysis. |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Universitas Setia Budi > Fakultas Farmasi > S1 Farmasi |
| Depositing User: | Unnamed user with email baa.si@setiabudi.ac.id |
| Date Deposited: | 22 Dec 2025 07:40 |
| Last Modified: | 22 Dec 2025 07:40 |
| URI: | https://eprints.setiabudi.ac.id/id/eprint/48 |
