EFEKTIVITAS KORTIKOSTEROID DALAM MENINGKATKAN TROMBOSIT PADAPASIEN DEMAM BERDARAH DENGUE DI RSUD Dr. MOEWARDI SURAKARTA : PERIODE JANUARI 2023 - DESEMBER 2024

Krista, El Shadday Bela (2025) EFEKTIVITAS KORTIKOSTEROID DALAM MENINGKATKAN TROMBOSIT PADAPASIEN DEMAM BERDARAH DENGUE DI RSUD Dr. MOEWARDI SURAKARTA : PERIODE JANUARI 2023 - DESEMBER 2024. Other thesis, Universitas Setia Budi.

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Abstract

Demam Berdarah Dengue (DBD) merupakan penyakit infeksi yang ditandai dengan penurunan jumlah trombosit (trombositopenia), yang dapat mempengaruhi tingkat kesembuhan pasien. Kortikosteroid seperti deksametason diketahui memiliki efek antiinflamasi dan imunosupresif yang berpotensi meningkatkan jumlah trombosit. Penelitian ini bertujuan untuk mengevaluasi efektivitas kortikosteroid dalam meningkatkan trombosit pada pasien DBD, serta membandingkan kecepatan pemulihan jumlah trombosit antara pasien yang mendapatkan terapi kortikosteroid dan non steroid. Penelitian ini menggunakan desain observasional retrospektif dengan data rekam medis pasien DBD di RSUD Dr. Moewardi Surakarta pada periode Januari 2023 hingga Desember 2024. Sampel dipilih secara purposive sampling sebanyak 56 pasien yang memenuhi kriteria inklusi dan eksklusi. Data jumlah trombosit sebelum dan sesudah pemberian terapi dianalisis menggunakan uji statistik Mann�Whitney. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan antara kelompok pasien yang diberi terapi kortikosteroid dan yang tidak. Namun, peningkatan trombosit rata-rata lebih tinggi pada kelompok tanpa kortikosteroid. Hal ini menunjukkan bahwa penggunaan kortikosteroid belum tentu memberikan hasil klinis yang lebih baik dalam pengelolaan pasien DBD. Dengue Hemorrhagic Fever (DHF) is an infectious disease characterized by a decrease in the number of platelets (thrombocytopenia), which can affect the patient's recovery rate. Corticosteroids such as dexamethasone are known to have anti�inflammatory and immunosuppressive effects that have the potential to increase platelet count. This study aimed to evaluate the effectiveness of corticosteroids in increasing platelets in Dengue patients, as well as to compare the recovery rate of platelet counts between patients receiving corticosteroid and non- steroidal therapy. This study used a retrospective observational design with medical record data of Dengue patients at Dr. Moewardi Surakarta Hospital in the period January 2023 to December 2024. The sample was selected by purposive sampling of 56 patients who met the inclusion and exclusion criteria. Data on platelet counts before and after therapy were analyzed using Mann-Whitney statistical tests. The results showed that there were significant differences between the groups of patients who were given corticosteroid therapy and those who were not. However, the average platelet increase was higher in the group without corticosteroids. This suggests that the use of corticosteroids does not necessarily provide better clinical outcomes in the management of Dengue patients.
Item Type: Thesis (Other)
Uncontrolled Keywords: Demam Berdarah Dengue, trombositopenia, kortikosteroid, analisis retrospektif. Dengue Hemorrhagic Fever, thrombocytopenia, corticosteroids, retrospective analysis.
Subjects: R Medicine > R Medicine (General)
Divisions: Universitas Setia Budi > Fakultas Farmasi > S1 Farmasi
Depositing User: Unnamed user with email baa.si@setiabudi.ac.id
Date Deposited: 22 Dec 2025 07:40
Last Modified: 22 Dec 2025 07:40
URI: https://eprints.setiabudi.ac.id/id/eprint/48

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